The Liberian man diagnosed with the ebola virus in the United States is "fighting for his life", a US health official has said.
Thomas Eric Duncan - the fist person to test positive for the deadly virus on American soil - was downgraded to critical condition by doctors treating him at hospital in Texas.
Dr Tom Frieden, director of the Centers for Disease Control (CDC), told CNN on Sunday that Mr Duncan "is fighting for his life".
He also said the patient was not being treated with the experimental drug ZMapp, which was used to treat two Americans who recovered after contracting the virus while working in West Africa.
Dr Frieden said the drug is "all gone" and is "not going to be available anytime soon".
It is not yet clear if ZMapp contributed to the two Americans' recovery.
Mr Duncan's ebola diagnosis raised concerns that the disease could spread in the US after killing more than 3,000 people in West Africa.
Authorities have dealt with some 100 inquiries from people who thought they might also have the disease, but there have been no other confirmed cases.
Dr Anthony Fauci, from the National Institutes of Health, said it is "extraordinarily unlikely" for an ebola outbreak to occur in the US.
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Gallery: August: Ebola Victims In Isolation
A sick man staggers through a makeshift ebola isolation ward in Liberia. The images released in August illustrate the scale of the difficulties in treating sufferers
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The sick are often left to die in the makeshift wards, sometimes former classrooms
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A woman tries to help her sick husband who trips and falls in one of the wards
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Liberia is struggling to contain the outbreak and the sick face dying in terrible isolation
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The wife of a sick man despairs as her husband lies on the floor after falling
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A child lies sick in an isolation ward in Liberia
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A medical worker with a young family in an isolation ward
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A sick woman lies in a classroom now used as an ebola isolation ward
Dr Frieden echoed that on Sunday, telling CNN he was confident that the virus would not spread in America.
Mr Duncan arrived in the country on 20 September after a 28-hour journey from Liberia via Brussels that spanned three flights and three continents.
He was initially sent home with antibiotics after his first visit to A&E, despite telling a nurse he had returned from Liberia.
The CDC has identified 10 people who had contact with Mr Duncan and who may have been exposed to the virus. They have been placed under isolation, and an additional 40 are being monitored though none have yet shown symptoms.
A family who hosted Mr Duncan and who were subsequently placed in a quarantined apartment, have now been allowed to leave the building.
Days before flying to Texas, Mr Duncan had helped a pregnant woman in Liberia who later died of ebola, a fact he concealed from Liberian airport officials before boarding the plane.
Liberian authorities have announced plans to prosecute Mr Duncan when he returns, accusing him of lying to airport officials about not having any contact with an infected person.
Dr Frieden said the case had raised awareness among US hospitals to check patients for potential risks, particularly those from the disease epicentre in West Africa.
On Saturday, officials dressed in biohazard suits escorted two passengers off a plane in New Jersey because they were believed to be from Liberia and exhibiting signs of illness during the flight.
An airport official was quoted by newspapers as saying CDC officials did not believe the pair - a man and his daughter - were sick with ebola. The official added that all other passengers on the flight from Brussels were cleared to leave the plane.
The governments of Guinea, Sierra Leone and Liberia are struggling to contain the worst outbreak on record of the deadly hemorrhagic fever.
The World Health Organisation on Friday updated its death toll from the virus to at least 3,439 out of 7,492 suspected, probable or confirmed cases.
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